PIPAC – Pressurized Intraperitoneal Aerosol Chemotherapy

Apart from the HIPEC (hot chemotherapy) treatment method, patients may be subjected to another treatment method, the pressurized intraperitoneal aerosol chemotherapy (PIPAC). In the first place, a radical and complex surgery (cytoreductive surgery) is performed in all tumorous areas in the abdomen.  Immediately afterwards and while the patient is still under anaesthesia, PIPAC is applied.

The chemotherapy drug under the PIPAC method is sprayed in the abdominal cavity as an aerosol for half an hour. It is performed in combination with laparoscopy only,  and not with open surgery (in the operation theatre under general anaesthesia). The pressurized intraperitoneal aerosol chemotherapy is applied to prolong life and to improve the comfort and quality of life of terminal patients , or in patients where hypothermic intraperitoneal chemotherapy (HIPEC) is not possible.  Though, typically, this method is not regarded as a palliative treatment, a peritoneal cancer disease may be treated with a combination of methods. Cytoreductive surgery, combined with PIPAC therapy is conducted at first. When PIPAC results in regression of metastases, HIPEC is applied as a second step for complete destruction of the remaining microscopic metastases. The PIPAC method, may, in this regard, be considered a ‘concealed weapon’.

It is of utmost importance to conduct the treatment of peritoneal cancer patients in specialized centres by experienced specialists and in terms of applying a multidisciplinary approach. The specialized peritoneal cancer treatment centre with Anadolu Medical Centre applies the HIPEC and PIPAC treatment methods.


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